Careers

ActivX Biosciences, Inc.® is a biopharmaceutical company located in La Jolla, California and is a wholly-owned subsidiary of Tokyo-based Kyorin Pharmaceutical Co. Ltd. ActivX utilizes its drug discovery and proteomics profiling capabilities (KiNativ®) to develop small molecules for unmet medical needs. The company applies its proprietary chemical technologies and high-throughput protein analysis to the drug discovery and development process to discover disease mechanisms and optimize drugs for these diseases.

ActivX Biosciences, Inc. provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, ActivX Biosciences, Inc. complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.




Scientist - Organic/Medicinal Chemistry

Job Descritpion

ActivX Biosciences is a biopharmaceutical company that develops small molecules for unmet medical needs. ActivX uses its chemoproteomics probe-based profiling technology to discover disease mechanisms and optimize drugs for these diseases.
ActivX is looking for a highly motivated Scientist with a desire to work in a fast-paced medicinal chemistry research group.
The researcher will participate in hit identification, hit-to-lead and lead optimization processes in an interdisciplinary team. The ideal candidate will be expected to develop viable synthetic strategies and to efficiently conduct multi-step syntheses of small-molecules from milligram- to multi-gram scale to support pre-clinical R&D. The selected candidate will analyze and develop structure-activity relationships to provide input to the design of new molecules with suitable potency, selectivity, pharmacokinetics, in vivo efficacy and safety profile. S/he may synthesize, purify and characterize active site probes to support ActivX’s technology platforms. S/he participates in multi-disciplinary group meetings, makes intellectual contributions to ensure success in ActivX’s drug discovery programs, and contributes to patent authorship. S/he stays current of scientific literature related to the state-of-the-art in organic synthesis and drug discovery.

Qualifications/REQUIREMENTS

• Ph.D. in Organic Chemistry with at least 2 years industrial or postdoctoral experience in synthetic organic chemistry or drug discovery.
• Extensive experience in the synthesis of a wide range of chemical compounds (synthesis of heterocycles, chiral synthesis, metal catalyzed reactions).
• Ability to analyze structure-activity relationships and in vitro/in vivo ADMET to provide input on project strategies.
• Proficiency with analytical techniques including LC-MS, NMR, UV, IR spectroscopy.
• Excellent multitasking skills with the ability to plan and execute multiple reactions simultaneously.
• Attention to detail, scientific curiosity and critical thinking abilities.
• Excellent oral and written communication skills.
• Strong interpersonal skills and ability to productively work in a multidisciplinary team.
• Track record of contributing to patent applications and journal publications is highly desirable.

Interested applicants should send their curriculum vitae and contact information to jobs@activx.com

Contact KiNativ™Contact ActivX

For more information about ActivX Targeted Probes or profiling needs please contact us.

ActivX Biosciences, Inc.
Telephone: (858) 558-5558
Fax: (858) 587-4878

Probes available from Thermo Scientific