Chemistry – Research Scientist

ActivX Biosciences seeks a talented, motivated Organic/Medicinal Chemist to join our drug discovery team. The researcher will participate in hit-to-lead and lead optimization processes in an interdisciplinary team to make contributions to ActivX’s drug discovery programs. Together, we will make new medicines for patients worldwide.

ActivX is in the Torrey Pines Science Park complex in La Jolla, California. Research at ActivX is focused on drug discovery in the therapeutic areas of viral infection, metabolic and inflammatory diseases. Our proprietary KiNativ™ technology is used extensively internally and also provides profiling services, on a fee-for-service basis, to most major pharmaceutical and biotech companies. Our technology allows the identification and development of highly selective drugs, significantly lowering development risks.

A successful candidate will have extensive training in synthetic organic chemistry, with a good understanding of medicinal chemistry principles.

Duties and Responsibilities

  • Develop viable synthetic strategies and conduct multi-step syntheses of small molecules, in line with levels of expectations, to support pre-clinical R&D.
  • Develop structure-activity relationships and analyze available data to provide input on the design of new molecules with improved potency and biopharmaceutical properties.
  • Actively participate in multidisciplinary project meetings.
  • Create relevant intellectual property and contribute to patent authorship.
  • Stay current of synthetic literature and scientific literature related to drug discovery.
  • May synthesize, purify and characterize active site probes to support ActivX’s technology platforms.


  • Ph.D. in Organic Chemistry with at least 2 years of industrial or postdoctoral experience in synthetic organic chemistry or drug discovery.
  • Ability to analyze structure-activity relationships and in vitro/in vivo ADMET.
  • Proficiency in analytical techniques including LC-MS, NMR, UV, IR spectroscopy.
  • Excellent multitasking skills with the ability to plan and execute multiple reactions simultaneously.
  • Critical thinking and scientific curiosity.
  • Attention to detail.
  • Excellent oral and written communication skills.
  • Strong interpersonal skills with the ability to work collaboratively in a team.
  • Track record of accomplishments in synthetic organic chemistry, medicinal chemistry or related disciplines is highly desirable.


Please submit your CV and cover letter at

Contact KiNativ™Contact ActivX

For more information about ActivX Targeted Probes or profiling needs please contact us.

ActivX Biosciences, Inc.
Telephone: (858) 558-5558
Fax: (858) 587-4878

Probes available from Thermo Scientific