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ActivX News Releases

02/08/10 Thermo Fisher Scientific Licenses Novel Activity-Based Protein Profiling Technology from ActivX Biosciences
01/04/10 ActivX Biosciences Head Receives Distinguished Scientist Award
08/21/08 ActivX Biosciences, Inc. Announces Positive Phase Ib and IIa Clinical Trial Results for KRP-104, a Flexible Dosing DPP-4 Inhibitor for Type 2 Diabetes
03/21/07 ActivX Biosciences Launches Breakthrough Kinase Platform, KiNativ™
03/15/06 ActivX/Kyorin Begins First U.S. Phase I Study for Novel Anti-Diabetic Drug
03/14/06 ActivX Biosciences Announces Expansion of Strategic Collaboration Agreement with Pfizer Inc. with Multiple Discovery and Developmental Stage Projects
02/10/05 Wall Street Reporter Interview with Dr. John Kozarich
02/09/05 ActivX Biosciences Announces Expansion of Strategic Collaboration Agreement with Pfizer Inc. with Multiple Discovery and Developmental Stage Projects
02/03/05 BioWorld Today article on Kyorin purchase of ActivX Biosciences
02/02/05 ActivX Biosciences Announces Closing of Aquisition by Kyorin Pharmaceutical Co., Ltd.
  Pre 2005 Press

 

ActivX Publications

06/2009 Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase
03/2009 Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)
02/2009 The Biochemistry of Disease: Desperately Seeking Syzygy
08/2008 Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta
05/2008 Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse
08/2007 Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity
01/2007 Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects
01/2007 Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor
01/2007 Functional Interrogation of the Kinome using Nucleotide Acyl Phosphates
10/2005 Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitorsent DPP7 inhibitors
10/2005 Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7
04/2005 Evaluation of Clinical Colon Carcinoma Using Activity-Based Proteomic Profiling
02/2005 High-resolution functional proteomics by active-site peptide profiling
01/2005 Wortmannin, a Widely Used Phosphoinositide 3-Kinase Inhibitor, also Potently Inhibits Mammalian Polo-like Kinase
07/2004 Synthesis of AX7593, a Quinazoline-Derived Photoaffinity Probe for EGFR
07/2004 The Development and Application of Methods for Activity-based Protein Profiling
05/2004 Design and Synthesis of AX7574: A Microcystin-Derived, Fluorescent Probe for Serine/Threonine Phosphatases
03/2004 Synergistic Computational and Experimental Proteomics Approaches for More Accurate Detection of Active Serine Hydrolases in Yeast
01/2004 Mapping Enzyme Active Sites in Complex Proteomes
01/2004 Chemical Strategies for Activity-Based Proteomics
08/2003 Prolyl peptidases: a serine protease subfamily with high potential for drug discovery
04/2003 Functional profiling of the proteome with affinity labels
04/2003 Proteomic Tools for Quantitation by Mass Spectrometry
06/2003 Discovering Potent and Selective Reversible Inhibitors of Enzymes in Complex Proteomes
02/2003 Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3+2] Cycloaddition
02/2003 Inhibitor Focusing: Direct Selection of Drug Targets from Proteomes Using Activity-Based Probes
02/2003 Activity-based proteomics: enzyme chemistry redux
09/2002 Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes
10/2002 Chemical strategies for functional proteomics
08/2002 Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
07/2002 Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
07/2002 Activity-based probes for functional proteomics
09/2001 Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes
03/2001 Profiling Serine Hydrolase Activities in Complex Proteomes
01/2001 Profiling the specific reactivity of the proteome with non-directed activity-based probes
02/2000 Chemical strategies for the global analysis of protein function
12/1999 Activity-based protein profiling: The serine hydrolases

    

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