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ActivX Biosciences Announces Agreement with Pfizer for Drug Profiling

July 10, 2003

LA JOLLA, California, July 10, 2003 – ActivX Biosciences, Inc., a privately held biotechnology company applying novel chemical technologies and high-throughput protein analysis to drug discovery, announced today it has entered into an agreement with Pfizer to further characterize the protein activity of a research compound currently under development at Pfizer.

Under the agreement, ActivX agreed to utilize its proprietary technology to analyze specific protein activities to provide a greater understanding of the biological activity of Pfizer’s compound. Financial terms of the transaction were not announced.

“We believe ActivX’s proprietary technology is well suited to rapidly and definitively characterize protein activity and thus should provide Pfizer with additional information to aid in its drug development efforts,” said John. W. Kozarich, PhD., President and CEO of ActivX.

With the addition of Pfizer, ActivX continues to validate its technology by further building a strong portfolio of corporate partnerships, which currently includes Kyorin Pharmaceutical Co. and Sosei Co.

ActivX Biosciences, Inc. (www.activx.com), a privately held biotechnology company in La Jolla, California, is applying proprietary chemical technologies and high-throughput protein analysis to the drug discovery process. By focusing on functional proteins, ActivX addresses disease mechanisms directly, in contrast to approaches such as expression profiling, in which the measured analyte is several steps removed from the site of drug action. ActivX and its partners are using its proprietary technology to address critical challenges in drug discovery, including selectivity profiling of candidate drug molecules across whole protein families in biological samples to guide their medicinal chemistry optimization; identifying novel drug targets and biomarkers; and characterizing off-target activities of candidate and established drugs to understand the basis for their efficacy and toxicity.

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Contact:
John W. Kozarich
ActivX Biosciences
858.558.5558
johnk@activx.com

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A wholly owned subsidiary of Kyorin Pharmaceutical Co, Ltd.
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